The Kansas City Chiefs, reigning AFC champions, are poised for another thrilling NFL season in 2025. With a schedule packed with high-stakes matchups, international games, and holiday showdowns, fans have much to anticipate. Let’s delve into the full schedule and offer predictions for each game.
The Kansas City Chiefs enter the 2025 NFL season as a team with massive expectations. After years of dominance under head coach Andy Reid and superstar quarterback Patrick Mahomes, the Chiefs are once again a top contender for the Super Bowl. With a tough slate of games including international appearances, holiday showdowns, and high-profile rematches their journey through the 2025 season promises drama, excitement, and must-watch football.
This blog dives deep into the Chiefs’ full 2025 schedule, week-by-week game predictions, major storylines, key player matchups, and what fans can realistically expect this year.
The Chiefs’ 2025 Season: What’s at Stake?
Coming off another strong postseason appearance in 2024, the Kansas City Chiefs are targeting a return to the Super Bowl. The stakes are higher than ever:
- Can Mahomes continue to redefine the quarterback position?
- Will the retooled defense withstand a barrage of high-octane offenses?
- How will the Chiefs fare in a league where everyone is gunning for them?
With the AFC West growing increasingly competitive and the NFL’s international and holiday game slate expanding, 2025 could be one of Kansas City’s most challenging seasons yet.
Week-by-Week Schedule & Game Predictions
Week 1: @ Los Angeles Chargers (São Paulo, Brazil)
- Date & Time: Friday, September 5, 7:15 PM CT
- Venue: Arena Corinthians, São Paulo
- Broadcast: YouTube (Free)
- Prediction: Chargers 27, Chiefs 24
The Kansas City Chiefs kick off the season with an international clash against the Chargers in Brazil. Despite Patrick Mahomes’ prowess, the Chargers’ familiarity with the Chiefs and the neutral venue could tilt the game in their favor.
Week 2: vs. Indianapolis Colts
- Date & Time: Sunday, September 14, 12:00 PM CT
- Venue: GEHA Field at Arrowhead Stadium
- Prediction: Chiefs 31, Colts 17
Returning home, the Chiefs face the Colts. With Mahomes leading the charge, Kansas City should secure a comfortable win.
Week 3: @ New York Giants (Monday Night Football)
- Date & Time: Monday, September 22, 7:15 PM CT
- Venue: MetLife Stadium
- Broadcast: ESPN
- Prediction: Chiefs 28, Giants 14
In their first primetime game, the Chiefs visit the Giants. Given the Giants’ rebuilding phase, Kansas City is favored to win.
Week 4: vs. Houston Texans
- Date & Time: Sunday, September 28, 12:00 PM CT
- Venue: GEHA Field at Arrowhead Stadium
- Prediction: Chiefs 30, Texans 21
Facing a young Texans squad, the Chiefs’ experience should prevail, especially at home.
Week 5: @ Jacksonville Jaguars
- Date & Time: Sunday, October 5, 12:00 PM CT
- Venue: TIAA Bank Field
- Prediction: Chiefs 27, Jaguars 20
The Jaguars present a challenge, but the Chiefs’ offense is expected to outpace Jacksonville’s defense.
Week 6: vs. Philadelphia Eagles
- Date & Time: Sunday, October 12, 3:25 PM CT
- Venue: GEHA Field at Arrowhead Stadium
- Prediction: Eagles 31, Chiefs 28
In a Super Bowl LIX rematch, the Eagles might edge out the Kansas City Chiefs in a closely contested game.
Week 7: @ Tennessee Titans
- Date & Time: Sunday, October 19, 12:00 PM CT
- Venue: Nissan Stadium
- Prediction: Chiefs 24, Titans 17
The Chiefs’ dynamic offense should overcome the Titans’ defense in this matchup.
Week 8: vs. Baltimore Ravens
- Date & Time: Sunday, October 26, 3:25 PM CT
- Venue: GEHA Field at Arrowhead Stadium
- Prediction: Chiefs 27, Ravens 24
In a battle of elite quarterbacks, Mahomes and the Kansas City Chiefs are poised to secure a narrow victory at home.
Week 9: vs. Washington Commanders
- Date & Time: Sunday, November 2, 12:00 PM CT
- Venue: GEHA Field at Arrowhead Stadium
- Prediction: Chiefs 28, Commanders 21
Hosting the Commanders, the Chiefs’ offense is expected to outmatch Washington’s defense.
Week 10: @ Buffalo Bills
- Date & Time: Sunday, November 9, 3:25 PM CT
- Venue: Highmark Stadium
- Prediction: Bills 30, Chiefs 27
In a high-stakes AFC showdown, the Bills might leverage home-field advantage to edge out the Kansas City Chiefs.
Week 11: vs. Detroit Lions
- Date & Time: Sunday, November 16, 12:00 PM CT
- Venue: GEHA Field at Arrowhead Stadium
- Prediction: Chiefs 31, Lions 28
Facing the Lions, the Kansas City Chiefs’ offense is expected to shine in a high-scoring affair.
Week 12: @ Las Vegas Raiders
- Date & Time: Sunday, November 23, 3:25 PM CT
- Venue: Allegiant Stadium
- Prediction: Chiefs 34, Raiders 20
In this divisional matchup, the Chiefs are anticipated to dominate the Raiders.
Week 13: @ Dallas Cowboys (Thanksgiving Day)
- Date & Time: Thursday, November 27, 3:30 PM CT
- Venue: AT&T Stadium
- Broadcast: CBS
- Prediction: Chiefs 28, Cowboys 24
In a marquee Thanksgiving game, Mahomes returns to his home state, aiming to lead the Chiefs to victory over the Cowboys.
Week 14: vs. Denver Broncos
- Date & Time: Sunday, December 7, 12:00 PM CT
- Venue: GEHA Field at Arrowhead Stadium
- Prediction: Chiefs 27, Broncos 17
Hosting the Broncos, the Chiefs are expected to continue their dominance in the AFC West.
Week 15: @ Los Angeles Chargers
- Date & Time: Sunday, December 14, 3:25 PM CT
- Venue: SoFi Stadium
- Prediction: Chargers 30, Chiefs 27
In a tightly contested game, the Chargers might leverage home advantage to secure a win.
Week 16: vs. Las Vegas Raiders
- Date & Time: Sunday, December 21, 12:00 PM CT
- Venue: GEHA Field at Arrowhead Stadium
- Prediction: Chiefs 35, Raiders 21
Back at home, the Chiefs are anticipated to overpower the Raiders once again.
Week 17: vs. Denver Broncos (Christmas Day)
- Date & Time: Thursday, December 25, 7:15 PM CT
- Venue: GEHA Field at Arrowhead Stadium
- Broadcast: Prime Video
- Prediction: Chiefs 31, Broncos 20
In a festive Christmas Day game, the Chiefs aim to gift their fans a victory over the Broncos.
Week 18: vs. Los Angeles Chargers
- Date & Time: Sunday, January 4, 12:00 PM CT
- Venue: GEHA Field at Arrowhead Stadium
- Prediction: Chiefs 28, Chargers 24
Closing the regular season, the Chiefs look to secure a win against the Chargers, potentially impacting playoff seeding.
Final Record Prediction: 13–4 Record
The Chiefs’ 2025 schedule presents a blend of challenging matchups and opportunities. With Mahomes at the helm and a roster brimming with talent, Kansas City is well-positioned to make another deep playoff run.
Key Players to Watch
Patrick Mahomes, QB
Still in his prime, Mahomes will likely surpass 5,000 passing yards again this season. His creativity and clutch playmaking are what make the Chiefs title contenders every year.
Travis Kelce, TE
Even with age, Kelce remains Mahomes’ favorite target. Look for him to be a red-zone monster and chain-mover throughout 2025.
Chris Jones, DT
Anchoring the defense, Jones is a nightmare for opposing quarterbacks. His ability to collapse the pocket gives KC’s secondary the time it needs.
Rashee Rice & Marquise Brown, WRs
Rice is developing into a reliable No. 1 receiver, while offseason acquisition Hollywood Brown brings elite speed and separation to stretch defenses.
Storylines to Follow
- International Game Impact: How will travel and the unfamiliar environment in Brazil affect the Week 1 opener?
- Thanksgiving and Christmas Games: These holiday matchups will define national perception. A loss could impact MVP races and playoff seeding.
- Divisional Rivalries: The Chargers and Raiders are always looking to knock off the division kings. Every AFC West game matters.
A Super Bowl or Bust Mentality
The Kansas City Chiefs are entering a defining season in their dynasty arc. With one of the league’s toughest schedules and all eyes on Mahomes, this team has little room for error. Fortunately, they have the leadership, experience, and firepower to turn this grueling path into another Super Bowl appearance.
From international clashes to historic holiday games, the 2025 season promises unforgettable moments—and Kansas City fans wouldn’t have it any other way.
